HCID 54711090, compound → HCID 54711100, compound

HRID 435822Notes

Reaction equation

HRID 435822 reaction equation
C([C:6]1[C:7](=[O:18])[NH:8][C:9]2[CH2:10][CH:11]([CH3:17])[CH2:12][CH2:13][C:14]=2[C:15]=1[OH:16])(OCC)=O>Cl>[OH:16][C:15]1[C:14]2[CH2:13][CH2:12][CH:11]([CH3:17])[CH2:10][C:9]=2[NH:8][C:7](=[O:18])[CH:6]=1

Participants

3

Reactant 1

HCID 54711090HCID 54711090, compound

Product 1

HCID 54711100HCID 54711100, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A suspension of 3-carboethoxy-4-hydroxy-7-methyl-5,6,7,8-tetrahydrocarbostyril (7.48 g; 0.03 mole) in 2N hydrochloric acid (50 ml) was refluxed 48 hrs. and the clear solution evaporated to dryness. After resolution in water and adjusting to pH 4.0 the precipitated white solid was filtered, washed well with water and recrystallised from acetic, m.p. >360°.

Workup

  1. temperaturewas refluxed 48 hrs
  2. customand the clear solution evaporated to dryness
  3. filtrationwas filtered
  4. washwashed well with water
  5. customrecrystallised from acetic, m.p. >360°

Sources & evidence

ORD record
ord-ef6b09e86fcb40578006ff6e9d362aa0
Source dataset
uspto-grants-1977_02
Patent number
US04006237

Reaction notes

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