Water → HCID 23662018, compound

HRID 435848Notes

Reaction equation

HRID 435848 reaction equation
[C:1]([C:4]1[CH:31]=[CH:30][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:26]=[CH:25][C:16]3[C:17](=[O:24])[CH:18]=[C:19]([C:21]([OH:23])=[O:22])[O:20][C:15]=3[C:14]=2[CH2:27][CH2:28][CH3:29])=[C:6]([CH2:32][CH2:33][CH3:34])[C:5]=1[OH:35])(=[O:3])[CH3:2].C(=O)(O)[O-].[Na+:40].O>C(O)C>[C:1]([C:4]1[CH:31]=[CH:30][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:26]=[CH:25][C:16]3[C:17](=[O:24])[CH:18]=[C:19]([C:21]([O-:23])=[O:22])[O:20][C:15]=3[C:14]=2[CH2:27][CH2:28][CH3:29])=[C:6]([CH2:32][CH2:33][CH3:34])[C:5]=1[OH:35])(=[O:3])[CH3:2].[Na+:40]

Participants

5

Reactant 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 12355883HCID 12355883, compound

Product 1

HCID 23662018HCID 23662018, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 5.0 parts of 7-[3-(4-acetyl-3-hydroxy-2-propyl phenoxy) propoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid dissolved in 200 parts of hot ethanol was added a solution of 0.870 parts of sodium bicarbonate in 30 parts of water. The solution was evaporated under reduced pressure to dryness, dry benzene was added and the mixture was again evaporated to dryness. The resulting buff solid was ground to a powder and dried to afford 5.0 parts of sodium 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylate.

Workup

  1. customThe solution was evaporated under reduced pressure to dryness, dry benzene
  2. additionwas added
  3. customthe mixture was again evaporated to dryness
  4. customdried

Sources & evidence

ORD record
ord-a77e2f33a3e7489594530a21b8f9d47c
Source dataset
uspto-grants-1977_02
Patent number
US04006245

Reaction notes

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