Sodium Bicarbonate → HCID 23683788, compound

HRID 435870Notes

Reaction equation

HRID 435870 reaction equation
[C:1]([C:4]1[C:31]([OH:32])=[CH:30][CH:29]=[CH:28][C:5]=1[O:6][CH2:7][CH:8]([OH:27])[CH2:9][O:10][C:11]1[C:16]2[C:17](=[O:26])[CH:18]=[C:19]([C:21]([O:23]CC)=[O:22])[O:20][C:15]=2[CH:14]=[CH:13][CH:12]=1)(=[O:3])[CH3:2].C(=O)(O)[O-].[Na+:37]>O>[C:1]([C:4]1[C:31]([OH:32])=[CH:30][CH:29]=[CH:28][C:5]=1[O:6][CH2:7][CH:8]([OH:27])[CH2:9][O:10][C:11]1[C:16]2[C:17](=[O:26])[CH:18]=[C:19]([C:21]([O-:23])=[O:22])[O:20][C:15]=2[CH:14]=[CH:13][CH:12]=1)(=[O:3])[CH3:2].[Na+:37]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 13090971HCID 13090971, compound

Product 1

HCID 23683788HCID 23683788, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

32.0 parts of ethyl 5-(3-[2-acetyl-3-hydroxyphenoxy]-2-hydroxypropoxy)-4-oxo-4H-1-benzopyran-2-carboxylate were refluxed with a solution of 6.08 parts of sodium bicarbonate in 200 parts of water for eighteen hours. The solution was filtered hot and cooled. The solid obtained was collected by filtration and crystallised from water containing a small quantity of ethanol to give 9.2 parts of sodium 5-(3-[2-acetyl-3-hydroxyphenoxy]-2-hydroxypropoxy)-4-oxo-4H-1-benzopyran-2-carboxylate, m.pt. 178°-180°.

Workup

  1. filtrationThe solution was filtered hot
  2. temperaturecooled
  3. customThe solid obtained
  4. filtrationwas collected by filtration
  5. customcrystallised from water containing a small quantity of ethanol

Sources & evidence

ORD record
ord-ad932101b55f4ad094fe99af29f88444
Source dataset
uspto-grants-1977_02
Patent number
US04006245

Reaction notes

Loading…