2,4-Dichlorobenzyl chloride → HCID 70637585, compound

HRID 435877Notes

Reaction equation

HRID 435877 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13].[H-].[Na+].[Cl:16][C:17]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:18]=1[CH2:19]Cl>>[Cl:16][C:17]1[CH:24]=[C:23]([Cl:25])[CH:22]=[CH:21][C:18]=1[CH2:19][O:13][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[CH2:6][C:2]1[NH:1][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 72122,4-Dichlorobenzyl chlorideHCID 24758Sodium hydrideHCID 23289325HCID 23289325, compound

Product 1

HCID 70637585HCID 70637585, compound

Procedure

Analogously to Example 1, 2.21 g. of (2,4-dichlorobenzyl)-[2-(1-imidazolymethyl)-phenyl]-ether, m.p. 108°-110°, is obtained from 1.74 g. of 2-(1-imidazolylmethyl)-phenol (Bull. Soc. Chim. France 1973, 1179), 300 mg. of sodium hydride suspension, and 1.41 g. of 2,4-dichlorobenzyl chloride.

Sources & evidence

ORD record
ord-fccf12e47db84cd082ec83fe492c9c88
Source dataset
uspto-grants-1977_02
Patent number
US04006243

Reaction notes

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