反应详情

2-Methyl-4-(5-t-butyl-1,3,4-thiadiazol-2-yl)-semicarbazide (0.1 mole) dissolved in methanol (100 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. Aqueous formaldehyde (0.2 mole; 37% concentration) is then added to the reaction vessel with stirring. Dilute aqueous potassium hydroxide is added to the reaction mixture to adjust the pH to between 7 and 8 and stirring is continued for a period of about 20 minutes resulting in the formation of a solid precipitate. The precipitate is recovered by filtration, is recrystallized and is dried under vacuum to yield the desired product 2-methyl-4-(5-t-butyl-1,3,4-thiadiazol-2-yl)-1,2,4-triazolidin-3-one.

1. additionis charged into a glass reaction vessel
2. customequipped with a mechanical stirrer
3. stirringstirring
4. customresulting in the formation of a solid precipitate
5. filtrationThe precipitate is recovered by filtration
6. customis recrystallized
7. customis dried under vacuum