Formaldehyde → 2-Methyl-4-(5-t-butyl-1,3,4-thiadiazol-2-yl)-1,2,4-triazolidin-3-one

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Reaction Steps

2-Methyl-4-(5-t-butyl-1,3,4-thiadiazol-2-yl)-semicarbazide (0.1 mole) dissolved in methanol (100 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. Aqueous formaldehyde (0.2 mole; 37% concentration) is then added to the reaction vessel with stirring. Dilute aqueous potassium hydroxide is added to the reaction mixture to adjust the pH to between 7 and 8 and stirring is continued for a period of about 20 minutes resulting in the formation of a solid precipitate. The precipitate is recovered by filtration, is recrystallized and is dried under vacuum to yield the desired product 2-methyl-4-(5-t-butyl-1,3,4-thiadiazol-2-yl)-1,2,4-triazolidin-3-one.

Provenance & Evidence