7-Aminocephalosporanic acid → HCID 178485193, compound

HRID 435942Notes

Reaction equation

HRID 435942 reaction equation
C(OC([NH:8][CH:9]([C:13]1[CH:18]=[CH:17][C:16]([N:19]([CH3:23])[C:20]([NH2:22])=[O:21])=[CH:15][CH:14]=1)[C:10]([OH:12])=O)=O)(C)(C)C.CC(O[CH2:28][C:29]1[CH2:38][S:37][C@@H:32]2[C@H:33]([NH2:36])[C:34](=[O:35])[N:31]2[C:30]=1[C:39]([OH:41])=[O:40])=O.[SH:42][C:43]1[N:44]=[N:45][NH:46][CH:47]=1>>[NH:46]1[CH:47]=[C:43]([S:42][CH2:28][C:29]2[CH2:38][S:37][C@@H:32]3[CH:33]([NH:36][C:10](=[O:12])[CH:9]([C:13]4[CH:14]=[CH:15][C:16]([N:19]([CH3:23])[C:20]([NH2:22])=[O:21])=[CH:17][CH:18]=4)[NH2:8])[C:34](=[O:35])[N:31]3[C:30]=2[C:39]([OH:41])=[O:40])[N:44]=[N:45]1

Participants

4

Reactant 3

HCID 4413287-Aminocephalosporanic acidHCID 54043199HCID 54043199, compoundHCID 178527738HCID 178527738, compound

Product 1

HCID 178485193HCID 178485193, compound

Procedure

When α-t-butoxycarbonylamino-p-(1-methylureido)phenylacetic acid is reacted with 7-ACA and 4-mercapto-1,2,3-triazole according to the procedure of Example 5, the title compound is obtained.

Sources & evidence

ORD record
ord-007d9ad792c24f3181eb68f6ccde10fb
Source dataset
uspto-grants-1977_02
Patent number
US04007173

Reaction notes

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