反应详情

A mixture of 15g. of 2-(2-isopropyl-1 -oxoindan-6-yl)propionic acid, 40g. of zinc amalgam, 50 ml. of conc. hydrochloride acid, 200 ml. of dioxane and 30 ml. of water was heated under reflux for 15 hours. After completion of the reaction, the reaction mixture was extracted with ether and the ether extract was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off from the extract and the residue was recrystallized from n-hexane to give 9.5g. of the desired product as colorless crystals of m.p. 90° - 91.5° C.

1. temperatureunder reflux for 15 hours
2. customAfter completion of the reaction
3. extractionthe reaction mixture was extracted with ether
4. extractionthe ether extract
5. washwas washed with water
6. dry with materialdried over anhydrous sodium sulfate
7. distillationThe solvent was distilled off from the
8. extractionextract
9. customthe residue was recrystallized from n-hexane
10. customto give 9.5g