Water → HCID 21454893, compound

HRID 435973Notes

Reaction equation

HRID 435973 reaction equation
[OH-].[K+].O.C([O:6][C:7]([C:9](C(OCC)=O)([CH2:24][CH3:25])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:23])[C:18]([O:20]CC)=[O:19])=[CH:13][CH:12]=1)=[O:8])C>C(O)C>[C:7]([CH:9]([CH2:24][CH3:25])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([CH3:23])[C:18]([OH:20])=[O:19])=[CH:13][CH:12]=1)([OH:8])=[O:6]

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 21454899HCID 21454899, compound

Product 1

HCID 21454893HCID 21454893, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a mixture of 14g. of potassium hydroxide, 100 ml. of water and 10 ml. of ethanol was added 14g. of ethyl 2-[4-(2,2-diethoxycarbonylbutyl)phenyl]propionate and the mixture was refluxed for 6 hours. The reaction mixture was treated with the same procedure as in Example 1 (2) to give 11.1g. of a pale yellow oil. The oil was heated at 160° - 170° C. for 3 hours and subjected to vacuum distillation to give 7.2g. of the desired product boiling at 230° C./0.05 mmHg. as a colorless oil.

Workup

  1. customto give 11.1g
  2. temperatureThe oil was heated at 160° - 170° C. for 3 hours
  3. distillationsubjected to vacuum distillation
  4. customto give 7.2g

Sources & evidence

ORD record
ord-d8e73122247644a0869b7773cfe2d984
Source dataset
uspto-grants-1977_02
Patent number
US04007179

Reaction notes

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