Hydrochloric Acid → HCID 70560654, compound

HRID 436040Notes

Reaction equation

HRID 436040 reaction equation
[NH2:1][C@H:2]([C:10]([NH:12][CH2:13][C:14]([N:16]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=1[C:25](=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:17])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO>[ClH:24].[NH2:1][C@H:2]([C:10]([NH:12][CH2:13][C:14]([N:16]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=1[C:25](=[O:32])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:17])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70559509HCID 70559509, compound

Product 1

HCID 70560654HCID 70560654, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4.5 g of L-phenylalanyl-N-(2-benzoyl-4-chlorophenyl)-N-methylglycinamide were dissolved in a minimum volume of methanol at room temperature and treated, by titration, with an exact equivalent of 1-N hydrochloric acid. The solvent was removed from the resulting solution by evaporation in vacuo at room temperature and finally by lyophilisation to give, in quantitative yield, L-phenylalanyl-N-(2-benzoyl-4-chlorophenyl)-N-methylglycinamide hydrochloride as a hygroscopic white light-sensitive amorphous powder of melting point 130°-150° C (slow decomposition): [α] D 20 = +41.7° (c = 1 in water).

Workup

  1. customThe solvent was removed from the resulting solution by evaporation in vacuo at room temperature and finally by lyophilisation

Sources & evidence

ORD record
ord-908b79e3c1c74bf78e7211b92888997e
Source dataset
uspto-grants-1977_02
Patent number
US04007219

Reaction notes

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