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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43605Generated: October 30, 2026

Lithium Hydroxide → HCID 86648580, compound

https://huagongshe.com/reaction/43605

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
ReactantEthyl cis(+/-)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-oxazole-4-carboxylateHCID 86648579—
SolventMethanolHCID 887—
ProductHCID 86648580HCID 8664858043%

Reaction Steps

The same operation as in Example (91d) was performed using ethyl cis(±)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-methoxypiperidin-1-yl)-1,3-oxazole-4-carboxylate obtained in Example (103e) (0.19 g, 0.45 mmol), 2 N lithium hydroxide (2 mL, 4 mmol) and methanol (3 mL), to obtain 76 mg of the title compound as a colorless solid (43%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-527889b1ff6245fa8c083bd8cdc56da5
Source noteuspto-grants-2013_09