3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester → HCID 612691, compound

HRID 436145Notes

Reaction equation

HRID 436145 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([NH2:9])[CH:3]=1.O=[C:11]1[CH2:15][S:14][CH2:13][CH:12]1[C:16](OC)=[O:17]>>[CH2:13]1[C:12]2[C:16](=[O:17])[NH:9][C:4]3[CH:3]=[CH:2][CH:7]=[CH:6][C:5]=3[NH:8][C:11]=2[CH2:15][S:14]1

Participants

3

Reactant 2

HCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 1645844-Fluorobenzene-1,2-diamine

Product 1

HCID 612691HCID 612691, compound

Procedure

In a similar fashion 4-fluoro-o-phenylenediamine is condensed with methyl tetrahydro-4-oxo-3-thiophenecarboxylate to give a mixture of 7-fluoro- and 6-fluoro-1,3,4,9-tetrahydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one.

Workup

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Sources & evidence

ORD record
ord-5b85e2b5ff1d4b7c936ad68483496796
Source dataset
uspto-grants-1977_02
Patent number
US04007272

Reaction notes

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