Hydrochloric Acid → HCID 21455284, compound

Participants

Reaction Conditions

Reaction Steps

2-Thioureido-5H-s-triazolo[5,1-a]isoindole (1.15 g, 0.005 mole) is suspended in 20 ml of 2% aqueous sodium hydroxide and 2.3 ml of 36% H2O2 (0.024 mole) is added at 40°-45° C. After 15 minutes, the mixture is heated for 5 minutes at 80° C then, after cooling and neutralizing with dilute hydrochloric acid, the resulting solid precipitate is recovered by filtration and is purified by crystallization from 60% ethanol. Yield 0.83 g; m.p. 261°-3° C.

Provenance & Evidence