Hydrochloric Acid → HCID 21455284, compound

HRID 436200Notes

Reaction equation

HRID 436200 reaction equation
[NH:1]([C:5]1[N:16]=[C:8]2[C:9]3[C:14]([CH2:15][N:7]2[N:6]=1)=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:2]([NH2:4])=S.[OH:17]O.Cl>[OH-].[Na+]>[NH:1]([C:5]1[N:16]=[C:8]2[C:9]3[C:14]([CH2:15][N:7]2[N:6]=1)=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:2]([NH2:4])=[O:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 86734483HCID 86734483, compound

Product 1

HCID 21455284HCID 21455284, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
80 °C

Procedure

2-Thioureido-5H-s-triazolo[5,1-a]isoindole (1.15 g, 0.005 mole) is suspended in 20 ml of 2% aqueous sodium hydroxide and 2.3 ml of 36% H2O2 (0.024 mole) is added at 40°-45° C. After 15 minutes, the mixture is heated for 5 minutes at 80° C then, after cooling and neutralizing with dilute hydrochloric acid, the resulting solid precipitate is recovered by filtration and is purified by crystallization from 60% ethanol. Yield 0.83 g; m.p. 261°-3° C.

Workup

  1. filtrationthe resulting solid precipitate is recovered by filtration
  2. customis purified by crystallization from 60% ethanol

Sources & evidence

ORD record
ord-70ca484c025543d6a0e0d3fc950a8185
Source dataset
uspto-grants-1977_02
Patent number
US04007276

Reaction notes

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