反应详情

83 g of bromoacetic acid methyl amide and 169 ml of 2,6-dimethyl aniline are stirred for 10 hours at 140° C bath temperature. The reaction mixture is left to stand overnight at room temperature. Next morning the contents of the flask are crystallised right through. The contents are filtered off and the precipitate is washed with benzene. The precipitate is subsequently dissolved in a small amount of water, the solution is brought to a pH of 10 to 11 with 30% sodium hydroxide solution and extracted with ether. The ethereal extract is dried over sodium sulphate, the ether distilled off in vacuo, and the residue is distilled in a high vacuum to yield 55 g of 2,6-dimethylanilinoacetic acid methyl amide (b.p. 152°-154° C/0.1 Torr). After recrystallisation from diisopropyl ether the product melts at 71°-73° C. 2,6-dimethylanilinoacetic acid dimethyl amide was manufactured in analogous manner: b.p. 132° C/0.3 Torr; m.p. 52°-54° C (recyrstallisation from diisopropyl ether/petroleum ether).

1. waitThe reaction mixture is left
2. customNext morning the contents of the flask are crystallised right through
3. filtrationThe contents are filtered off
4. washthe precipitate is washed with benzene
5. dissolutionThe precipitate is subsequently dissolved in a small amount of water
6. extractionextracted with ether
7. extractionThe ethereal extract
8. dry with materialis dried over sodium sulphate
9. distillationthe ether distilled off in vacuo
10. distillationthe residue is distilled in a high vacuum