反应详情

A mixture of 118 g. (0.33 moles) of ethyl α-bromo-3-chloro-4-cyclohexylphenylacetate is vigorously stirred at 130°-140° C with 29 g. (0.5 moles) of potassium fluoride in 100 ml. of ethylene glycol for 12 hours. The reaction mixture is cooled and 400 ml. of water is added and the crude product separates. The aqueous glycol mixture is extracted with ether, the ether is then dried, evaporated to dryness and upon distillation results in ethyl α-fluoro-3-chloro-4-cyclohexylphenylacetate.

1. additionA mixture of 118 g
2. temperatureThe reaction mixture is cooled
3. extractionThe aqueous glycol mixture is extracted with ether
4. dry with materialthe ether is then dried
5. customevaporated to dryness and upon distillation
6. customresults in ethyl α-fluoro-3-chloro-4-cyclohexylphenylacetate