m-Chloroperbenzoic acid → HCID 21452387, compound

HRID 436402Notes

Reaction equation

HRID 436402 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([NH:9][C:10]1[NH:11][C:12]2[CH:18]=[CH:17][CH:16]=[CH:15][C:13]=2[N:14]=1)=[S:8].ClC1C=CC=C(C(OO)=O)C=1>C(Cl)(Cl)Cl>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]1[S:8][N:11]2[C:10](=[N:14][C:13]3[CH:15]=[CH:16][CH:17]=[CH:18][C:12]=32)[N:9]=1

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 54072285HCID 54072285, compound

Product 1

HCID 21452387HCID 21452387, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To 0.51 g. of 2-(2-pyrazinylthiocarbonylamino)-benzimidazole [(IV), R = 2-pyrazinyl] in 200 ml. of chloroform at 20°-30° C. (room temperature) is added 0.5 g. of m-chloroperbenzoic acid. The reaction mixture is allowed to stand for 15 hours (overnight) and washed with 20 ml. of potassium bicarbonate solution, 20 ml. of water and dried over magnesium sulfate. The chloroform is evaporated and the residue is recrystallized from methanolchloroform to yield 2-(2-pyrazinyl)-1,2,4-thiadiazolo-[2,3-a]-benzimidazole [(I), R = 2-pyrazinyl].

Workup

  1. wash(overnight) and washed with 20 ml
  2. dry with materialof water and dried over magnesium sulfate
  3. customThe chloroform is evaporated
  4. customthe residue is recrystallized from methanolchloroform

Sources & evidence

ORD record
ord-f409ea7b31844bf4af825c4d8febfe5a
Source dataset
uspto-grants-1977_02
Patent number
US04009164

Reaction notes

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