1-(2-Hydroxyethyl)-4-methylpiperazine → HCID 68117674, compound

HRID 436424Notes

Reaction equation

HRID 436424 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9]O)[CH2:4][CH2:3]1.[Na].[CH3:12][O:13][C:14]1[CH:31]=[CH:30][C:17]([CH:18]=[CH:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][N:21]=2)=[CH:16][CH:15]=1>>[CH3:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([CH:18]=[CH:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([OH:26])=[O:25])=[CH:22][N:21]=2)=[CH:30][CH:31]=1.[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH3:9])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 2311841-(2-Hydroxyethyl)-4-methylpiperazineHCID 5360545SodiumHCID 54158325HCID 54158325, compound

Product 1

HCID 68117674HCID 68117674, compound

Procedure

The apparatus and procedures of Example 3 were used, employing 2-(N-methyl-N'-piperazinyl)ethan-1-ol (42.7 g.), sodium (0.2 g.), methyl 6-p-methoxystyrylnicotinate (13.46 g.), and a temperature of 70° C. for 8 hours. The crude ester was treated to give the dimaleate of N-methyl-N'-ethylpiperazine 6-p-methoxystyrylnicotinate, m.p. 214°-215° C.

Sources & evidence

ORD record
ord-aacd620d8f114ec387a82eaa5049a13e
Source dataset
uspto-grants-1977_02
Patent number
US04009174

Reaction notes

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