1-(2-Hydroxyethyl)-4-methylpiperazine → HCID 21452637, compound

HRID 436426Notes

Reaction equation

HRID 436426 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9]O)[CH2:4][CH2:3]1.[Na].[CH3:12][O:13][C:14]1[CH:31]=[CH:30][C:17]([CH2:18][CH2:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][N:21]=2)=[CH:16][CH:15]=1>>[CH3:12][O:13][C:14]1[CH:15]=[CH:16][C:17]([CH2:18][CH2:19][C:20]2[CH:29]=[CH:28][C:23]([C:24]([OH:26])=[O:25])=[CH:22][N:21]=2)=[CH:30][CH:31]=1.[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH3:9])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 2311841-(2-Hydroxyethyl)-4-methylpiperazineHCID 5360545SodiumHCID 53636602HCID 53636602, compound

Product 1

HCID 21452637HCID 21452637, compound

Procedure

The apparatus and procedures of Example 3 were used, employing 2-(N-methyl-N'-piperazinyl)ethan-1-ol (21.35 g.), sodium (0.1 g.), methyl 6-p-methoxyphenethylnicotinate (13.56 g.), and a temperature of 170° C. for 6 hours. The crude ester was treated to give the dimaleate of N-methyl-N'-ethylpiperazine 6-p-methoxyphenethylnicotinate, m.p. 200° C.

Sources & evidence

ORD record
ord-c65de862e798408bb20d4e8c8efeda86
Source dataset
uspto-grants-1977_02
Patent number
US04009174

Reaction notes

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