HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 436430Generated: October 26, 2026
Hydrochloric Acid → 1-Hydrazinyl-3,4-dihydroisoquinoline
https://huagongshe.com/reaction/436430
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 3,4-Dihydro-isoquinolin-1-ylamine | HCID 9793824 | — |
| Reactant | 1-Ethoxy-3,4-dihydroisoquinoline | HCID 12349038 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-Hydrazinyl-3,4-dihydroisoquinoline | HCID 12349041 | — |
Reaction Steps
A mixture of 1-amino-3,4-dihydroisoquinoline (VI: R=R'=Y=Y'=Z=Z'=H) hydrochloride (m.p. 133°-134° C., 0.5 g.), prepared from 1-ethoxy-3,4-dihydroisoquinoline and ammonium chloride, sodium carbonate (0.38 g.), hydrazine (0.41 g.) and ethanol (15 ml.) was stirred (at 25° C.). The mixture was filtered. An ether solution of the crystals which separated from the filtrate on chilling was washed with water, dried and filtered. Concentration of the filtrate and crystallization of the residue from ether afforded 1-hydrazino-3,4-dihydroisoquinoline (0.44 g.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04009170 |
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| Source dataset | uspto-grants-1977_02 |
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| ORD ID | ord-c56f3b2b50184e3084ea8ec85fc05f53 |
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| Source note | uspto-grants-1977_02 |
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