Acetone → 1-(2-Isopropylidenehydrazino)-6,7-dimethoxy-3,4-dihydroisoquinoline
Reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:5][N:4]=1)[NH2:2].Cl.[CH3:18][C:19]([CH3:21])=O>>[C:19](=[N:2][NH:1][C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:15][CH3:16])=[C:10]([O:13][CH3:14])[CH:11]=2)[CH2:6][CH2:5][N:4]=1)([CH3:21])[CH3:18]Participants
4
Procedure
In a manner similar to that of Example 25, condensation of 1-hydrazino-6,7-dimethoxy-3,4-dihydroisoquinoline (7.0 g.) and acetone (100 ml.) and treatment of the reaction mixture with hydrochloric acid afforded 1-(2-isopropylidenehydrazino)-6,7-dimethoxy-3,4-dihydroisoquinoline (I: X = X' = CH3, Y = Y' = H, Z = Z' = CH3O) hydrochloride (7.55 g., m.p. 211.5°-213° C. with decomposition).
Sources & evidence
- ORD record
- ord-cc5e18a524934b0195d6fbcc4a5b9863
- Source dataset
- uspto-grants-1977_02
- Patent number
- US04009170
Reaction notes
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