反应详情

To a solution of 23.6 grams of 2-phenyl-3-acetylbenzofuran in 100 milliliters of isopropanol were added 4.2 grams of paraformaldehyde and 19.1 grams of N-methylpiperazine dihydrochloride and the mixture was heated under gentle reflux for a period of 12 hours. The dihydrochloride of the compound named in the heading of this example precipitated from the reaction mixture and was separated therefrom by suction filtration, washed with a small quantity of ethanol, and recrystallized from ethanol. The dihydrochloride had a melting point of 174°-177°C and 22.8 grams thereof was thus obtained.

1. temperaturethe mixture was heated
2. temperatureunder gentle reflux for a period of 12 hours
3. customprecipitated from the reaction mixture
4. customwas separated
5. filtrationby suction filtration
6. washwashed with a small quantity of ethanol
7. customrecrystallized from ethanol
8. customthereof was thus obtained