Hydrochloric Acid → HCID 53705719, compound

HRID 436514Notes

Reaction equation

HRID 436514 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH:8]([C:15]([OH:17])=[O:16])[CH2:7][CH2:6][C:5]2=1.Cl.[CH2:19](O)[CH3:20]>>[CH2:19]([O:16][C:15]([CH:8]1[CH2:7][CH2:6][C:5]2[C:4]3[C:12](=[CH:13][CH:14]=[C:2]([CH3:1])[CH:3]=3)[NH:11][C:10]=2[CH2:9]1)=[O:17])[CH3:20]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 21452688HCID 21452688, compound

Product 1

HCID 53705719HCID 53705719, compound

Procedure

6-Methyl-1,2,3,4-tetrahydrocarbazole-2-carboxylic acid (10 g.) was dissolved in 300 ml. of warm ethanol and 5 ml. of 7N alcoholic hydrogen chloride was added. The solution was thoroughly mixed and allowed to remain at room temperature for 2 days. After cooling in an ice bath for 5 hours, the mixture was filtered and washed with several volumes of ethanol. Upon drying, a yield of 7.3 g. of 6-methyl-1,2,3,4-tetrahydrocarbazole-2-carboxylic acid ethyl ester, m.p. 117°-118° , was obtained.

Workup

  1. additionThe solution was thoroughly mixed
  2. temperatureAfter cooling in an ice bath for 5 hours
  3. filtrationthe mixture was filtered
  4. washwashed with several volumes of ethanol
  5. customUpon drying

Sources & evidence

ORD record
ord-561de63833e3424fbba450b4314edbae
Source dataset
uspto-grants-1977_02
Patent number
US04009181

Reaction notes

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