HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-(2-Chloroethyl)methanesulphonamide | HCID 89092 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 4-Acetamino-3-methyl-N-ethylaniline | HCID 21452831 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline | HCID 21452834 | — |
Reaction Steps
A mixture of 57.6g of 4-acetamino-3-methyl-N-ethylaniline, 52g of βmethanesulfonamidoethyl chloride, 27.7g of sodium hydrogen carbonate, 70g of water and 70ml of methanol were refluxed for 5 hours, and thereafter the methanol was distilled out under reduced pressure. Water was added to the reaction system and an oily product separated out. This oily product was poured into ethyl acetate and cooled to obtain white 4-acetamino-3-methyl-N-(β-methanesulfonamidoethyl)-N-ethylaniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04009205 |
| Source dataset | uspto-grants-1977_02 |
| ORD ID | ord-0415ffa5af224365b1f5a0fffd76f923 |
| Source note | uspto-grants-1977_02 |