Hydrazine hydrate (1:1) → HCID 20361254, compound

HRID 436560Notes

Reaction equation

HRID 436560 reaction equation
O.NN.[F:4][C:5]1[CH:6]=[CH:7][C:8]2[N:14]3[C:15]([CH2:18][O:19][N:20]4C(=O)C5=CC=CC=C5C4=O)=[N:16][N:17]=[C:13]3[CH2:12][N:11]=[C:10]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C:9]=2[CH:37]=1>C(O)C>[NH2:20][O:19][CH2:18][C:15]1[N:14]2[C:8]3[CH:7]=[CH:6][C:5]([F:4])=[CH:37][C:9]=3[C:10]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[N:11][CH2:12][C:13]2=[N:17][N:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 20361186HCID 20361186, compound

Product 1

HCID 20361254HCID 20361254, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 2, a solution of hydrazine hydrate in ethanol is reacted at 65° C. with 8-fluoro-1-[(phthalimidooxy)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine to give 1-[(aminooxy)methyl]-8-fluoro-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-c4160cc5586b463bb37952995d4212c1
Source dataset
uspto-grants-1977_02
Patent number
US04009175

Reaction notes

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