反应详情

A mixture of 1.5 g of 2-allyl-4-fluorophenol, 3.1 g of 8-(3-chloropropyl)-1-phenyl-4-oxo-1,3,8-triazaspiro[4,5]decane, 0.7 g of potassium carbonate and 40 ml of toluene was heated under reflux for 10 hours. After cooling, the reaction mixture was washed with water, dried over sodium sulfate and evaporated under reduced pressure. The residue was triturated with ether, cooled and filtered to give 8-{3-(2-allyl-4-fluorophenoxy)propyl}-1-phenyl-4-oxo-1,3,8-triazaspiro[4,5]decane, m.p. 110° - 113° C; recrystallized from cyclohexane, m.p. 117° - 117.5° C.

1. temperaturewas heated
2. temperatureunder reflux for 10 hours
3. temperatureAfter cooling
4. washthe reaction mixture was washed with water
5. dry with materialdried over sodium sulfate
6. customevaporated under reduced pressure
7. customThe residue was triturated with ether
8. temperaturecooled
9. filtrationfiltered