Bromocyclopentane → HCID 21452877, compound

HRID 436645Notes

Reaction equation

HRID 436645 reaction equation
[OH:1][C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:25])[C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)=[O:7])=[CH:4][CH:3]=1.[CH:28]1(Br)[CH2:32][CH2:31][CH2:30][CH2:29]1.C(=O)([O-])[O-].[K+].[K+]>>[CH:28]1([O:1][C:2]2[CH:27]=[CH:26][C:5]([C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:25])[C:18]3[CH:19]=[CH:20][C:21]([O:24][CH:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:22][CH:23]=3)=[O:7])=[CH:4][CH:3]=2)[CH2:32][CH2:31][CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 8728BromocyclopentaneHCID 11430Potassium CarbonateHCID 21452870HCID 21452870, compound

Product 1

HCID 21452877HCID 21452877, compound

Procedure

m.p. 153°-154° C., 18.8 g., was prepared as in Example 29 using 18.5 g. of N,N'-heptamethylenebis(4-hydroxybenzamide), 29.8 g. of cyclopentyl bromide, 20.7 g. of potassium carbonate, 500 ml. of isoamyl alcohol and recrystallization from acetonitrile.

Workup

  1. custom, was prepared as in Example 29 using 18.5 g
  2. customof isoamyl alcohol and recrystallization from acetonitrile

Sources & evidence

ORD record
ord-3e00c4a73a2c434f9639c11226c588fe
Source dataset
uspto-grants-1977_02
Patent number
US04009208

Reaction notes

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