1-Bromo-3-hydroxypropan-2-one → HCID 86734821, compound

HRID 436786Notes

Reaction equation

HRID 436786 reaction equation
[NH:1]([C:3]1[CH2:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])[C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[N:4]=1)[NH2:2].[Br:21][CH2:22][C:23](=O)[CH2:24][OH:25]>O1CCCC1>[Br:21][CH2:22][C:23](=[N:2][NH:1][C:3]1[CH2:9][N:8]=[C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])[C:6]2[CH:17]=[CH:18][CH:19]=[CH:20][C:5]=2[N:4]=1)[CH2:24][OH:25]

Participants

4

Reactant 2

HCID 117448281-Bromo-3-hydroxypropan-2-oneHCID 12612344HCID 12612344, compound

Product 1

HCID 86734821HCID 86734821, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, 2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1-bromo-3-hydroxypropanone under nitrogen to give 2-[[2-bromo-1-(hydroxymethyl)ethylidene]-hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-79b243487c054f678707f6cc1c60d206
Source dataset
uspto-grants-1977_06
Patent number
US04028356

Reaction notes

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