1,5-Dichloropentan-2-one → HCID 54486573, compound

HRID 436792Notes

Reaction equation

HRID 436792 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][NH2:13])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1.[Cl:22][CH2:23][C:24](=O)[CH2:25][CH2:26][CH2:27][Cl:28]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][N:13]=[C:24]([CH2:25][CH2:26][CH2:27][Cl:28])[CH2:23][Cl:22])[CH2:9][N:8]=[C:7]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:20])[C:6]=2[CH:21]=1

Participants

4

Reactant 2

HCID 2629781,5-Dichloropentan-2-oneHCID 123908757-Chloro-5-(2-chlorophenyl)-2-hydrazinyl-3H-1,4-benzodiazepine

Product 1

HCID 54486573HCID 54486573, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the manner given in Example 1, 7-chloro-2-hydrazino-5-(o-chlorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1,5-dichloro-2-pentanone under nitrogen to give 7-chloro-2-[[2-chloro-1-(3-chloropropyl)ethylidene]hydrazino]-5-(o-chlorophenyl)-3H-1,4-benzodiazepine.

Sources & evidence

ORD record
ord-37fea10896a04cfca8c269f7eb11a531
Source dataset
uspto-grants-1977_06
Patent number
US04028356

Reaction notes

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