反应详情

Sodium (92 mg) was dissolved in 5 ml of absolute methyl alcohol with moderate cooling. To this solution 2-hydroxypyrazolo[1,5-a]pyridine (500 mg) was added and then dimethyl sulfate (500 mg) was added. The mixture was stirred for 30 min. at room temperature and refluxed for 8 hr. The reaction mixture was concentrated to remove methyl alcohol, and water was added to the residue. The solution was extracted with n-hexane, and the n-hexane solution was dried over sodium sulfate. The dried n-hexane solution was concentrated and the residue was distilled to give 280 mg of oily product under reduced pressure.

1. temperaturerefluxed for 8 hr
2. concentrationThe reaction mixture was concentrated
3. customto remove methyl alcohol, and water
4. additionwas added to the residue
5. extractionThe solution was extracted with n-hexane
6. dry with materialthe n-hexane solution was dried over sodium sulfate
7. concentrationThe dried n-hexane solution was concentrated
8. distillationthe residue was distilled