反应详情

Into a solution of 3-t-butyl-5-isoxazolyl isocyanate (2.84 g) in toluene (51 ml) is introduced methylamine (1.58 g) at room temperature. The mixture is stirred at room temperature for 2 hours and then at 50° C. for 4 hours. The reaction mixture is evaporated to remove the solvent, and the residue is recrystallized from ethyl acetate to give 1-methyl-3-(3-t-butyl-5-isoxazolyl)urea (2.80 g) as crystals melting at 195.0° to 196.0° C. (decomp.). The yield is 83.6%.

1. waitat 50° C. for 4 hours
2. customThe reaction mixture is evaporated
3. customto remove the solvent
4. customthe residue is recrystallized from ethyl acetate