HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 436826Generated: October 30, 2026
Methyl isothiocyanate → HCID 21431587, compound
https://huagongshe.com/reaction/436826
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 3-Tert-butyl-1,2-oxazol-5-amine | HCID 2095694 | — |
| Catalyst | Triethylamine | HCID 8471 | — |
| Product | HCID 21431587 | HCID 21431587 | 52.7% |
Reaction Steps
A mixture of 3-t-butyl-5-aminoisoxazole (2.07 g), methyl isothiocyanate (1.40 g) and triethylamine (3 drops) is heated at 75° C. for 72 hours. The reaction mixture is chromatographed on a column of silica gel, whereby 1-methyl-3-(3-t-butyl-5-isoxazolyl)thiourea (1.66 g) is obtained as an oil. IR: 1622 cm-1 (CC14).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04028376 |
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| Source dataset | uspto-grants-1977_06 |
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| ORD ID | ord-2282e198e46c4508bbed759ae18d8e4b |
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| Source note | uspto-grants-1977_06 |
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