4-(1,3-Thiazol-2-yl)butan-1-amine → N-[1-(Methylsulfanyl)-2-nitroethenyl]-4-(1,3-thiazol-2-yl)butan-1-amine

HRID 436852Notes

Reaction equation

HRID 436852 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[S:7][CH:8]=[CH:9][N:10]=1.[CH3:11][S:12]([C:14](SC)=[CH:15][N+:16]([O-:18])=[O:17])=O>CO>[CH3:11][S:12][C:14]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[S:7][CH:8]=[CH:9][N:10]=1)=[CH:15][N+:16]([O-:18])=[O:17]

Participants

4

Reactant 2

HCID 179312574-(1,3-Thiazol-2-yl)butan-1-amineHCID 544870941-Nitro2-methylthio-2-methylsulphinylethylene

Product 1

HCID 71391849N-[1-(Methylsulfanyl)-2-nitroethenyl]-4-(1,3-thiazol-2-yl)butan-1-amine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of 2-(4-aminobutyl)thiazole (1.56 g) in methanol (35 ml) was added dropwise over 30 minutes to a stirred solution of 1-methylsulphinyl-1-methylthio -2-nitroethylene (1.81 g) in methanol (60 ml). The product was isolated as in the previous Examples and recrystallised from isopropanol to give the title product, m.p. 75.5°-76°.

Workup

  1. customrecrystallised from isopropanol

Sources & evidence

ORD record
ord-099572d981be4a4e8526a74035aaf758
Source dataset
uspto-grants-1977_06
Patent number
US04028379

Reaction notes

Loading…