Acetic Acid → HCID 21431786, compound

HRID 436925Notes

Reaction equation

HRID 436925 reaction equation
[CH:1]1([C:7]([C:9]2[CH:14]=[CH:13][C:12](CC#N)=[CH:11][CH:10]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(=O)(=O)(O)O.[C:23]([OH:26])(=[O:25])[CH3:24]>O>[CH:9]1([C:7]([C:1]2[CH:2]=[CH:3][C:4]([CH2:24][C:23]([OH:26])=[O:25])=[CH:5][CH:6]=2)=[O:8])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 21431779HCID 21431779, compound

Product 1

HCID 21431786HCID 21431786, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

4-cyclohexylcarbonylphenylacetonitrile (1.5 g.), water (1.5 ml.), concentrated sulphuric acid (1.5 ml.) and acetic acid (1.5 ml.) were heated under reflux for 6 hours, cooled, poured into water and extracted with ether. Removal of the solvent and crystallisation from cyclohexane gave the acid, m.p. 94°-95.5°.

Workup

  1. temperatureunder reflux for 6 hours
  2. temperaturecooled
  3. extractionextracted with ether
  4. customRemoval of the solvent and crystallisation from cyclohexane
  5. customgave the acid, m.p. 94°-95.5°

Sources & evidence

ORD record
ord-f0bac9bdc3094ef4b917066c8f7467f7
Source dataset
uspto-grants-1977_06
Patent number
US04028404

Reaction notes

Loading…