Hydrochloric Acid → HCID 70633860, compound

HRID 436959Notes

Reaction equation

HRID 436959 reaction equation
C(OC([NH:8][C@H:9]([C:18]([NH:20][CH2:21][C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([C:38]([NH:40][C@H:41]([C:46]([OH:48])=[O:47])[CH2:42][CH:43]([CH3:45])[CH3:44])=[O:39])[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:28])[CH3:26])=[O:23])=[O:19])[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][CH:12]=1)=O)(C)(C)C.[ClH:49]>O1CCOCC1>[ClH:49].[NH2:8][C@H:9]([C:18]([NH:20][CH2:21][C:22]([NH:24][C@H:25]([C:27]([NH:29][C@H:30]([C:38]([NH:40][C@H:41]([C:46]([OH:48])=[O:47])[CH2:42][CH:43]([CH3:44])[CH3:45])=[O:39])[CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)=[O:28])[CH3:26])=[O:23])=[O:19])[CH2:10][C:11]1[CH:12]=[CH:13][C:14]([OH:17])=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54452714HCID 54452714, compound

Product 1

HCID 70633860HCID 70633860, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The N-t-butoxycarbonyl-L-tyrosylglycyl-L-alanyl-L-phenylalanyl-L-leucine is dissolved in 100 parts dioxane and stirred with a ten-fold excess of 2 N HCl in dioxane at room temperature for 15 minutes. The solvent is then removed under reduced pressure and the residue triturated with ethyl ether. The resulting solid is precipitated from the mixture of methanol and ether to afford L-tyrosylglycyl-L-alanyl-L-phenylalanyl-L-leucine hydrochloride.

Workup

  1. customThe solvent is then removed under reduced pressure
  2. customthe residue triturated with ethyl ether
  3. customThe resulting solid is precipitated from the mixture of methanol and ether

Sources & evidence

ORD record
ord-d98c0412203e42d1bbf8c1a99bf5e26c
Source dataset
uspto-grants-1977_06
Patent number
US04028319

Reaction notes

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