Phosgene → 7-Bromobenzothiazol-2-yl isocyanate

HRID 436989Notes

Reaction equation

HRID 436989 reaction equation
[C:1](Cl)(Cl)=[O:2].[NH2:5][C:6]1[S:7][C:8]2[C:14]([Br:15])=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1>C(OCC)(=O)C>[Br:15][C:14]1[C:8]2[S:7][C:6]([N:5]=[C:1]=[O:2])=[N:10][C:9]=2[CH:11]=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 203571127-Bromo-1,3-benzothiazol-2-amine

Product 1

HCID 536464587-Bromobenzothiazol-2-yl isocyanate

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A saturated solution of phosgene in ethyl acetate (200 ml) is charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. 2-Amino-7-bromobenzothiazole (0.1 mole) is added with stirring. After this time the mixture is cooled, and the solid product formed is recovered by filtration. The solid is then dried to yield the desired product 7-bromobenzothiazol-2-yl isocyanate dimer.

Workup

  1. customequipped with a mechanical stirrer
  2. temperaturethermometer and reflux condenser
  3. temperatureAfter this time the mixture is cooled
  4. customthe solid product formed
  5. filtrationis recovered by filtration
  6. customThe solid is then dried

Sources & evidence

ORD record
ord-fb605949bd4b4f18bd09d45d3413db1a
Source dataset
uspto-grants-1977_06
Patent number
US04029491

Reaction notes

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