反应详情

To ethyl β-oxocyclohexanepropionate (4.4 g, 0.234 mole) in n-propanol (500 ml) is added dropwise with stirring under nitrogen at 80° C. methylhydrazine (13.8 g, 0.3 mole). After heating at reflux during 5 hours, the reaction is cooled and evaporated to a residual oil. Crystallization from ethylacetate gives a white powder mp 170.5° C. to 172° C.

1. temperatureAfter heating
2. temperatureat reflux during 5 hours
3. temperaturethe reaction is cooled
4. customevaporated to a residual oil
5. customCrystallization from ethylacetate