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温度

0 °C

To 100 ml of a 50:50 (v/v) methanol/water solution containing 14.35 g of potassium carbonate, was added n-butyl 2-tert-butoxyacetate (6.50 g, 0.0346 mol). The mixture was heated at reflux for 17 hours and the volatiles removed on a flash evaporator. The remaining solution was cooled to approximately 0° C. and acidified to pH 3-4 with cold 50% aqueous hydrogen chloride. The product was extracted with ether, the ether extract washed with brine and dried over magnesium sulfate, then concentrated in vacuo to give the title compound as a yellow liquid.

1. temperatureThe mixture was heated
2. temperatureat reflux for 17 hours
3. customthe volatiles removed on a flash evaporator
4. extractionThe product was extracted with ether
5. extractionthe ether extract
6. washwashed with brine
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated in vacuo