Prostaglandin E2 → 16,16-Dimethylprostaglandin E

Participants

Reaction Steps

Further, following the procedure of Preparation 16, but using in place of the C-15 unsubstituted PGE2 -type compound of Preparation 16 and above, the 15-methyl and 15-methyl ether PGE2 -type compounds described above, there are obtained the corresponding 15-methyl and 15-methyl ether PGE1 -type compounds of either 15-epimeric configuration in both free acid and methyl ester form. Further, following the procedure of Preparation 16 but using in place of the C-16 unsubstituted PGE2 -type compound therein the 16-methyl or 16,16-dimethyl-PGE2 -type compounds described above there are obtained the corresponding 16-methyl or 16,16-dimethyl-PGE1 -type compounds of this invention. Finally, following the procedure of Preparation 16, but using the various 17-substituted phenyl PGE2 -type compounds described above there are obtained the corresponding 17-substituted phenyl-PGE1 -type compounds. The compounds in this paragraph represent the nvel PGE1 -type compounds of this invention.

Provenance & Evidence