Methanethiol → HCID 21430201, compound

HRID 437109Notes

Reaction equation

HRID 437109 reaction equation
[C:1]1([S:7]([CH:9](Br)[CH3:10])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na].[CH3:13][SH:14]>C(#N)C>[C:1]1([S:7]([CH:9]([S:14][CH3:13])[CH3:10])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 878MethanethiolHCID 5360545SodiumHCID 11207033Benzene, [(1-bromoethyl)sulfinyl]-

Product 1

HCID 21430201HCID 21430201, compoundYield 75.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

832 mg of (1-bromoethyl) phenyl sulfoxide was dissolved in 1 ml. of acetonitrile, and with addition of 3.3 ml. of a 20% aqueous solution of sodium salt of methyl mercaptan, the mixture was heated at 40° C. for 10 hours. The product was extracted with 50 ml. of chloroform, and dried with anhydrous sodium sulfate. The solvent was removed at reduced pressure, and the product was separated by column-chromatography (silica gel, chloroform). There was obtained 170 mg of 1-methylthioethyl phenyl sulfoxide in a yield of 75.4%.

Workup

  1. extractionThe product was extracted with 50 ml
  2. dry with materialof chloroform, and dried with anhydrous sodium sulfate
  3. customThe solvent was removed at reduced pressure
  4. customthe product was separated by column-chromatography (silica gel, chloroform)

Sources & evidence

ORD record
ord-2bc2f7fc5c864f19b839de52ec486dac
Source dataset
uspto-grants-1977_06
Patent number
US04029712

Reaction notes

Loading…