1-Methylpiperazine → HCID 178480778, compound

HRID 437117Notes

Reaction equation

HRID 437117 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]2[N:6]=[C:7](SC)[NH:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]2[N:6]=[C:7]([N:20]3[CH2:21][CH2:22][N:17]([CH3:16])[CH2:18][CH2:19]3)[NH:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 178503343HCID 178503343, compound

Product 1

HCID 178480778HCID 178480778, compoundYield 89.7%

Conditions

Temperature
140 °C

Procedure

A mixture of 3.2 g of 7-chloro-3-methylthio-2H-1,2,4-benzothiadiazine 1,1-dioxide and 1.1 g of 1-methylpiperazine is heated with stirring in an oil bath at 140° C. for 2 hours. After cooling, the resultant solid is recrystallized from a mixture of dimethylformamide and water to give 3.1 g of the desired product, m.p. above 300° C.

Workup

  1. temperatureis heated
  2. temperatureAfter cooling
  3. customthe resultant solid is recrystallized from a mixture of dimethylformamide and water

Sources & evidence

ORD record
ord-4347ae61b1c145d7b964886a7515a798
Source dataset
uspto-grants-1977_06
Patent number
US04029780

Reaction notes

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