Hydrochloric Acid → HCID 178480779, compound

HRID 437124Notes

Reaction equation

HRID 437124 reaction equation
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[N:6]=[C:7]([N:12]3[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]3)[NH:8][S:9](=[O:11])(=[O:10])[C:4]=2[CH:3]=1.Cl>O>[ClH:1].[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[N:6]=[C:7]([N:12]3[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]3)[NH:8][S:9](=[O:10])(=[O:11])[C:4]=2[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178480778HCID 178480778, compound

Product 1

HCID 178480779HCID 178480779, compoundYield 185.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a suspension of 3.0 g of 7-chloro-3-(4-methyl-1-piperazinyl)-2H-1,2,4-benzothiadiazine 1,1-dioxide in 12 ml of water is added dropwise 1.5 ml of concentrated hydrochloric acid. The mixture is heated on a stream bath until it becomes a clear solution, which precipitates crystals on cooling. There is obtained 3.1 g of the desired product, m.p. 277°-281° C. (decomposition).

Workup

  1. temperatureThe mixture is heated on a stream bath until it
  2. customprecipitates crystals
  3. temperatureon cooling

Sources & evidence

ORD record
ord-36de00eb23d441f8bfa76f9fbeeba768
Source dataset
uspto-grants-1977_06
Patent number
US04029780

Reaction notes

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