Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → HCID 54050166, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Isobutyl chloroformate | HCID 62365 | — |
| 반응물 | N-methylethoxycarbohydrazide | HCID 11217246 | — |
| 반응물 | Boc-ala-pro-OH | HCID 11902919 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 54050166 | HCID 54050166 | — |
반응 단계
To 0.16 mole of t-butoxycarbonylalanylproline in 80 ml of dry tetrahydrofuran which has been cooled to -20° to -30° is added 2 ml of N-methylmorpholine and then 2.1 ml of isobutylchloroformate. After stirring for 10 minutes, 0.16 mole of 2-azaalanine ethyl ester and 60 ml of chloroform are added. The reaction mixture is allowed to warm to room temperature overnight, concentrated in vacuo, taken up in ethyl acetate and the insoluble material removed by filtration. Concentration of the filtrate in vacuo gives t-butoxycarbonylalanylprolyl-2-azaalanine ethyl ester.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04029772 |
| 출처 데이터셋 | uspto-grants-1977_06 |
| ORD ID | ord-cdf07bab250249fb945d48ca9defdeb9 |
| 출처 메모 | uspto-grants-1977_06 |