Trifluoroacetic acid → Trifluoroacetic acid

HRID 437130Notes

Reaction equation

HRID 437130 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[N:5]([CH3:26])[NH:6][C:7](=[O:25])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:24])[C@H:14]([CH3:23])[NH:15]C(OC(C)(C)C)=O)[CH3:2].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:27])[N:5]([CH3:26])[NH:6][C:7](=[O:25])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:24])[C@H:14]([CH3:23])[NH2:15])[CH3:2].[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54050166t-Butoxycarbonylalanylprolyl-2-azaalanine ethyl ester

Product 2

HCID 6422Trifluoroacetic acidHCID 22798119Alanylprolyl-2-azaalanine ethyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the t-butoxycarbonylalanylprolyl-2-azaalanine ethyl ester obtained above is added 15 ml of methylene chloride. The reaction mixture is cooled to 0° and 15 ml of trifluoroacetic acid added. After stirring for 1 hour at 0° and 1 hour at room temperature, the reaction mixture is concentrated in vacuo to yield alanylprolyl-2-azaalanine ethyl ester as its trifluoroacetic acid salt.

Workup

  1. temperatureThe reaction mixture is cooled to 0°
  2. concentrationthe reaction mixture is concentrated in vacuo

Sources & evidence

ORD record
ord-75808748f0954fe383c21631eb32c6ca
Source dataset
uspto-grants-1977_06
Patent number
US04029772

Reaction notes

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