HCID 21430523, compound → HCID 21430509, compound

HRID 437137Notes

Reaction equation

HRID 437137 reaction equation
[NH2:1][CH2:2][CH2:3][NH:4][C:5]([NH:7][C:8]1[C:17]([Cl:18])=[C:16]2[C:11]([C:12]([O:19][CH3:20])=[N:13][CH:14]=[N:15]2)=[CH:10][CH:9]=1)=S>C(O)C>[Cl:18][C:17]1[C:8]([NH:7][C:5]2[NH:4][CH2:3][CH2:2][N:1]=2)=[CH:9][CH:10]=[C:11]2[C:16]=1[N:15]=[CH:14][N:13]=[C:12]2[O:19][CH3:20]

Participants

3

Reactant 1

HCID 21430523HCID 21430523, compound

Product 1

HCID 21430509HCID 21430509, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of the thiourea prepared above (0.4 g) in ethanol (50 ml.) was stirred under reflux conditions (78°) with mercuric oxide (0.5 g) for 4 hours and filtered while hot. Evaporation of the filtrate yielded a white solid which was recrystallised from ethanol to give 0.1 g of 8-chloro-7-(2-imidazolin-2-ylamino)-4-methoxyquinazoline as a free base, m.p. 238°-239°.

Workup

  1. filtrationfiltered while hot
  2. customEvaporation of the filtrate
  3. customyielded a white solid which
  4. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-e96e17fa6a914c42935d20ab0d8d4912
Source dataset
uspto-grants-1977_06
Patent number
US04029792

Reaction notes

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