Hydrochloric Acid → HCID 21430445, compound

Participants

Reaction Steps

183 Grams of 4-chloro-3-sulfamoylbenzoic acid-morpholide (0.6 mole) were stirred with 0.3 l of N-methylpiperazine for 3 hours at 130° C. Subsequently the excess base was eliminated in vacuo, the residue was dissolved in 0.5 l of water, and the pH of the solution was adjusted to 7 by means of 5N HCl. After having stood in the refrigerator for several days, the reaction product which had separated in a crystalline form was suction-filtered and was recrystallized from ethanol of 90% strength.

Provenance & Evidence