Hydrochloric Acid → HCID 21430445, compound

HRID 437155Notes

Reaction equation

HRID 437155 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[O:7])=[CH:4][C:3]=1[S:16](=[O:19])(=[O:18])[NH2:17].[CH3:20][N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.Cl>O>[ClH:1].[CH3:20][N:21]1[CH2:26][CH2:25][N:24]([C:2]2[CH:15]=[CH:14][C:5]([C:6]([N:8]3[CH2:13][CH2:12][O:11][CH2:10][CH2:9]3)=[O:7])=[CH:4][C:3]=2[S:16](=[O:19])(=[O:18])[NH2:17])[CH2:23][CH2:22]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 531671-MethylpiperazineHCID 53993156HCID 53993156, compound

Product 1

HCID 21430445HCID 21430445, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

183 Grams of 4-chloro-3-sulfamoylbenzoic acid-morpholide (0.6 mole) were stirred with 0.3 l of N-methylpiperazine for 3 hours at 130° C. Subsequently the excess base was eliminated in vacuo, the residue was dissolved in 0.5 l of water, and the pH of the solution was adjusted to 7 by means of 5N HCl. After having stood in the refrigerator for several days, the reaction product which had separated in a crystalline form was suction-filtered and was recrystallized from ethanol of 90% strength.

Workup

  1. waitAfter having stood in the refrigerator for several days
  2. customthe reaction product which had separated in a crystalline form
  3. filtrationwas suction-filtered
  4. customwas recrystallized from ethanol of 90% strength

Sources & evidence

ORD record
ord-71fa9e9de4724b968d7ba8cc996a647b
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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