Hydrochloric Acid → HCID 21430482, compound

Participants

Reaction Steps

16 Grams of diethylsulfate were added dropwise, at room temperature, while being mixed in a vibro-mixer, to a solution of 31.5 g of 3-dimethylsulfamoyl-4-(piperazine-1-yl)-benzoic acid (0.1 mole), which had been prepared according to Example 15, in 0.3 l of 1N NaOH. The mixture was allowed to react for another 3 hours while being mixed in the vibro-mixer. Subsequently the solution was acidified with 5N HCl, and the separated hydrochloride was recrystallized from ethanol and water.

Provenance & Evidence