Hydrochloric Acid → HCID 21430482, compound

HRID 437160Notes

Reaction equation

HRID 437160 reaction equation
[CH2:1](OS(OCC)(=O)=O)[CH3:2].[CH3:10][N:11]([CH3:30])[S:12]([C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1[N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[C:18]([OH:20])=[O:19])(=[O:14])=[O:13].[ClH:31]>[OH-].[Na+]>[ClH:31].[CH2:1]([N:27]1[CH2:26][CH2:25][N:24]([C:23]2[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][C:15]=2[S:12](=[O:13])(=[O:14])[N:11]([CH3:30])[CH3:10])[CH2:29][CH2:28]1)[CH3:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6163Diethyl SulfateHCID 21430464HCID 21430464, compound

Product 1

HCID 21430482HCID 21430482, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

16 Grams of diethylsulfate were added dropwise, at room temperature, while being mixed in a vibro-mixer, to a solution of 31.5 g of 3-dimethylsulfamoyl-4-(piperazine-1-yl)-benzoic acid (0.1 mole), which had been prepared according to Example 15, in 0.3 l of 1N NaOH. The mixture was allowed to react for another 3 hours while being mixed in the vibro-mixer. Subsequently the solution was acidified with 5N HCl, and the separated hydrochloride was recrystallized from ethanol and water.

Workup

  1. customhad been prepared
  2. customto react for another 3 hours
  3. additionwhile being mixed in the vibro-mixer
  4. customthe separated hydrochloride was recrystallized from ethanol and water

Sources & evidence

ORD record
ord-5a52014d55aa4a80bdf9a56143fa1b4c
Source dataset
uspto-grants-1977_06
Patent number
US04029787

Reaction notes

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