Isobutylamine → HCID 21430469, compound

Participants

Reaction Steps

40 Grams of 3-dimethylsulfamoyl-4-(4-methylpiperazine-1-yl)-benzoylchloride-hydrochloride (0.1 mole) were introduced portionwise, while stirring, into a solution of 30 g of isobutylamine in 0.4 l of tetrahydrofurane. The mixture, whose temperature rose to about 50° C., was subsequently heated for another 10 minutes under reflux and was then concentrated to half its volume.

Provenance & Evidence